ODCs

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1 OMIM reference -
2 associated genes
11 signs/symptoms

COMMON GENES: 2
PROTEIN INTERACTIONS: 2
COMMON SIGNS: 5

1 OMIM reference -
3 associated genes
6 signs/symptoms

Brachydactyly type C

Brachydactyly type A2


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	BMPR1B BMPR1B	(0.9) (0.9)	BMP2 GDF5

Citations in the biomedical literature:

Brachydactyly type C		Brachydactyly type A2
	Synonym(s): (no synonyms)		Synonym(s): - Brachydactyly, Mohr-Wriedt type

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - 1 MeSH reference: C537093		External references: 1 OMIM reference - 1 MeSH reference: C537089


COMMON SIGNS	- Autosomal dominant inheritance - Clinodactyly of fifth finger - Metacarpal anomalies / Archibald's sign - Short foot / brachydactyly of toes - Short hand / brachydactyly

Brachydactyly type C		Brachydactyly type A2
	Very frequent - Ulnar deviation of fingers Frequent - Cone epiphyses / epiphysis - Thin / hypoplastic / hyperconvex fingernails Occasional - Short stature / dwarfism / nanism - Symphalangy of fingers - Talipes-valgus		Occasional - Terminal / third phalangeal bone of fingers hypoplasia